Etopophos etoposide phosphate for injection is an antineoplastic agent which is available for intravenous infusion as a sterile lyophile in singledose vials containing etoposide phosphate equivalent to 100 mg etoposide, 32. The remaining seven phase studies ii, 29 34 used ifosfamide in combinations that did not include an anthracycline. Tap along the timeline to move to different parts of the audio file. Ifex ifosfamide for injection, usp singledose vials for constitution and administration by intravenous infusion each contain 1 gram or 3 grams of sterile ifosfamide. Please refer to full prescribing information, including boxed warning.
Ifosfamide for injection ifosfamide for injection, usp singledose vials for constitution and administration by intravenous infusion each contain 1 gram or 3 grams of sterile ifosfamide. The total daily dose of mesnex is 100% of the ifosfamide dose. The molecular formula is c 7 h 15 cl 2 n 2 o 2 p and its molecular weight is 261. Dosage and duration of treatment andor treatment intervals depend on the. Mesna equivalent of 40% total daily ifosfamide dose given as iv bolus postifosfamide mesna equivalent of 40% total daily ifosfamide dose given orally 2 and 6 hours after the end of the ifosfamide infusion. A high fluid intake will help prevent bladder irritation. This typically regresses after completing treatment. Ifosfamide can damage the lining of your bladder, causing bleeding into your urine.
Ifosfamide can also cause hypophosphatemic rickets. Ifosfamide is a parenterally administered alkylating agent similar to cyclophosphamide that is used in the treatment of several forms of cancer including lymphomas, sarcoma and advanced forms of solid organ cancer such as breast, testicular, ovarian, gastric and lung cancer. Ifex is an alkylating drug indicated for use in combination with certain other. Ifosfamide is passed into the breast milk and may cause neutropenia, thrombocytopenia, low haemoglobin concentrations and diarrhea in children. Store intact vials at room temp or under refrigeration.
Assay preparation select an accurately counted number of containers of ifosfamide for injection, the combined contents of which are equivalent to about 6 g of ifosfamide. Voorma, ingevolge het besluit van het college voor promoties. Ixempra ixabepilone dosing and administration guide. Ifosfamide can be toxic to the bladder, and may cause hemorrhagic cystitis, a condition associated with bladder irritation and blood in the urine.
Mesnex mesna is a detoxifying agent to inhibit the hemorrhagic cystitis induced by ifosfamide. Accidental release measures contain spill and collect, as appropriate. Pdf addition of ifosfamide and etoposide to standard. Neurotoxicity related to the use of ifosfamide is a wellknown complication. Ifosfamide is 32chloroethyl22chloroethylaminotetrahydro2h1,3,2oxazaphosphorine 2oxide. Ifosfamide has been included in various salvage regimens after relapse following bep therapy. For more information, go to edit pdf content in word. The active ingredient, mesna, is a synthetic sulfhydryl compound designated as sodium2mercaptoethane sulfonate with a molecular formula of c 2 h 5 nao 3 s 2 and a molecular weight of 164. Mesnex is indicated as a prophylactic agent in reducing. Ifosfamide therapy is associated with minor transient serum enzyme elevations and has been linked to cases of acute. Ifex ifosfamide for injection, usp 1 gm single dose vial. Ifosfamide fda prescribing information, side effects and. Mesna can either be given to you as a short injection, or mixed into the drip solution with your ifosfamide, or as tablets.
Mesnex may be given on a fractionated dosing schedule of three bolus intravenous injections as outlined below. Before using ifosfamide, inform your doctor about your current list of medications, over the counter products e. A new drug combination, ifosfamide and etoposide, was highly effective in patients with. The length of treatment depends on how well your body responds to treatment with. Rinse each container with water, and add the rinsings to the volumetric flask. Mesnex tablets are given orally in a dosage equal to 40% of the ifosfamide dose 2 and 6 hours after each dose of ifosfamide. Aim is given to shrink tumors and alleviate symptoms of sarcoma. Dailymed ifex ifosfamide injection, powder, for solution. Mesnex injection is given as intravenous bolus injections in a dosage equal to 20% of the ifosfamide dosage ww at the time of ifosfamide administration. We do not have evidence of the benefit of adding etoposide and ifosfamide in the. Ifosfamide is contraindicated for breastfeeding see section 4.
This medication is given by injection into a vein by a health care professional. Pdf ewings sarcoma and primitive neuroectodermal tumor of bone are closely. The acute tubular dysfunction can be manifested by increased excretion of potassium, phosphorus, and magnesium. Guidelines for the administration of mesna with ifosfamide. While, a good pdf to word converter will make things quite easy and simple, allowing users to retain the same layout, format and image quality in the word output as original pdf, to. Your doctor knows this can happen and, if necessary, he or she will give you a medicine called mesna which will protect your bladder. Sections or subsections omitted from the full prescribing information are. Store in accordance with information listed on the product insert. Rituixmab binds to the surface of the cancer cell, while ifosfamide. Encourage your child to drink twice the normal amount of fluids for 24 hours after ifosfamide is given. While the use of methylene blue is a known antidote, symptomatic treatment of the central nervous system cns effects. Germ cell tumors with somatic transformation into pnet have in certain cases been successfully treated with chemotherapy that includes cycles of.
Following activation in the liver, ifosfamide interferes with dna through formation of phosphotriesters and dnadna crosslinks, thereby inhibiting protein synthesis and dna synthesis. Confusion and coma have been associated with the use of ifosfamide, and antiepileptic drugs may be required. Some health conditions may make you more susceptible to the sideeffects of the drug. Click on the rituximab package insert below for reported side effects and. Contain spills with an inert absorbent material such as soil, sand or oil dry. Ifosfamide ifo, sold under the brand name ifex among others, is a chemotherapy medication used to treat a number of types of cancer. Two of s the rct 10, 12 reported that the addition of ifosfamide to an anthracycline regimen either doxorubicin, or doxorubicin and dtic significantly. Ifosfamide definition of ifosfamide by medical dictionary.
Find medication information including related drug classes, side effects, patient statistics and answers to frequently asked questions. Ifosfamide side effects, dosage, interactions drugs. Ifosfamide interferes with oogenesis and spermatogenesis. Because of the potential for serious adverse events and the tumorigenicity shown for ifosfamide in animal studies, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Ifosfamide exhibits dosedependent pharmacokinetics in humans.
The dosage is based on your medical condition, body size, and response to treatment. Mesnex injection is given as intravenous bolus injections in a dosage equal to 20% of the ifosfamide dosage weight by weight ww at the time of ifosfamide administration and 4 and 8 hours after each dose of ifosfamide. Injections are prepared for parenteral use by adding sterile water for injection, usp, or. Ifosfamide powder for solution for injection drug summary. Avoid runoff into storm sewers, ditches, and waterways. Word will convert the pdf to editable text and you can then copy and paste that text into your office document. The vial and vial stopper are not made with natural rubber latex. Ifosfamide ifx is an agent as yet unstudied in advanced. Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. Ifosfamide can pass into breast milk and may harm a nursing baby. Find patient medical information for ifosfamidemesna intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. You may be able to overcome this with stronger flavored herbs such as basil, sage, or thyme. The most efficient way to insert pdf into word editable, multipage if you want to insert a multipage pdf into word and edit on the inserted pdf as well, the most efficient way is to do a pdf to word conversion. Ifosfamide, carboplatin, and cisplatin can cause renal complications, including acute tubular dysfunction, although carboplatin is less nephrotoxic than cisplatin.
This includes testicular cancer, soft tissue sarcoma, osteosarcoma, bladder cancer, small cell lung cancer, cervical cancer, and ovarian cancer. Dissolve the contents of each container in water and combine all of the solutions in a ml volumetric flask. Ifosfamide comes as powder to be mixed with liquid to be injected over at least 30 minutes intravenously into a vein by a doctor or nurse in a medical facility. Ifosfamide solution for injection drug information, side. Risk factors for ifosfamide nephrotoxicity include. Due to its urotoxic effect, ifex should not be administered without the use of a uroprotective agent such as mesna. Ifosfamide medical definition merriamwebster medical. Ifex ifosfamide for injection singledose vials for constitution and administration by intravenous infusion each contain 1 gram or 3 grams of sterile ifosfamide. Aim may be given with the goal of cure, and while not always curative, it may still relieve symptoms and prolong life. Eastern cooperative oncology group phase ii trial of ifosfamide in. Mesna can be given as an intravenous iv injection or as a tablet. Pdf successful treatment of ifosfamide neurotoxicity. If youre looking to insert the contents of your pdf file into an office file, as opposed to simply inserting the pdf as an attachment, then your best bet is to open that pdf with word 20 or 2016. However, as this emedtv segment explains, your ifosfamide dosage will be calculated using your weight, height, and other medical conditions, among other factors.
Johns wort may decrease ixabepilone plasma concentrations unpredictably and should be avoided safety information. Ifosfamide is 32chloroethyl22chloroethylaminotetrahydro2h1,3,2. Ifosfamide, like cyclophosphamide, is an oxazophosphorine alkylating agent. The most common adverse reactions in chemotherapyinduced nausea and vomiting in. Ifosfamide is a synthetic structural isomer of cyclophosphamide that has been approved for concurrent use with other drugs usually cisplatin, etoposide, or vinblastine in the treatment of metastatic germcell testicular cancer and some especially pediatric sarcomas. Potential adverse reactions from prescribed doses and overdoses are described in the package insert.
Ifosfamide is given intravenously by iv usually once a day for five days every three weeks. Ifosfamide is listed in the worlds largest and most authoritative dictionary database of abbreviations and acronyms. Ifex ifosfamide dose, indications, adverse effects. Purposealkylating agents have modest activity in advanced urothelial carcinoma. Clinical pharmacology of ifosfamide and metabolites. Animal studies indicate that the drug is capable of causing gene mutations and. Ifosfamidebased combination chemotherapy in advanced soft. Ifosfamide is removed from the body through the kidneys. Used as an antineoplastic agent in treatment of leukemia, lymphoma, and cancers of the lung, ovary, testes, and other organs.587 593 545 139 313 260 568 1 890 769 369 596 1186 207 1254 1189 1513 416 445 221 772 133 695 632 488 206 757 804 1429 796 971 979 94 225 695 1147 900 437